1 Ocak 2019 Dergi makalesi Açık Erişim

Onat, Bora; Ulusan, Sinem; Banerjee, Sreeparna; Erel-Goktepe, Irem

JSON-LD (schema.org)

{
  "@context": "https://schema.org/", 
  "@id": 74303, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biotechnol, TR-06800 Ankara, Turkey", 
      "name": "Onat, Bora"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Ulusan, Sinem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
      "name": "Banerjee, Sreeparna"
    }, 
    {
      "@type": "Person", 
      "name": "Erel-Goktepe, Irem"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on precast hydrogels coated with TA-Cipro/PVCL multilayers. LbL coating also provided enhanced Cipro release from the hydrogel surface at 37 degrees C compared to bare hydrogels. TA-Cipro/PVCL coated hydrogels showed antibacterial activity through chitosan and temperature-induced release of Cipro from multilayers. Chitosan and Cipro showed a coordinated antibacterial effect on Eschericia coli and Bacillus cereus, reducing their minimum inhibitory concentration (MIC). This effect was more pronounced on B. cereus. LbL modification of chitosan-based hydrogels using stimuli responsive polymers can be advantageous for bringing multiple functionalities to these materials without sacrificing their intrinsic properties such as antibacterial activity and biocompatibility. Such LbL-coated hydrogels hold promise in wound treatment as they may promote fibroblast proliferation and skin tissue regeneration.", 
  "headline": "Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels", 
  "identifier": 74303, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Multifunctional layer-by-layer modified chitosan/poly(ethylene glycol) hydrogels", 
  "url": "https://aperta.ulakbim.gov.tr/record/74303"
}