1 Ocak 2019 Dergi makalesi Açık Erişim

Kose, Duygu; Cadirci, Elif; Halici, Zekai; Sirin, Busra; Dincer, Busra

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{
  "@context": "https://schema.org/", 
  "@id": 73699, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
      "name": "Kose, Duygu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
      "name": "Cadirci, Elif"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
      "name": "Halici, Zekai"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
      "name": "Sirin, Busra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Binali Yildirim Univ, Dept Pharmacol, Fac Pharm, TR-24100 Erzincan, Turkey", 
      "name": "Dincer, Busra"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Aim This study aimed to investigate the role of the 5-HT7 receptor in fever mechanisms and its possible effect on the antipyretic mechanism of paracetamol. Materials and methods The study consisted of eight experimental groups and one control group. Group I: healthy, II: LPS, III: LPS + PARA, IV: LPS + AGO, V: LPS + ANTA, VI: LPS + AGO + ANTA, VII: LPS + AGO + PARA, VIII: LPS + ANTA + PARA, and IX: LPS + AGO + ANTA + PARA. Rectal temperatures were measured with a rectal thermometer. At the end of the experiment, tissues were examined molecularly. Real-time PCR mRNA expression analyses were performed for the 5-HT7 receptor, IL-6, and TNF-alpha in hypothalamus tissue. Results The mean differences in rectal temperature increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group and decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the healthy group. The IL-6 and TNF-alpha mRNA expression increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group in the 2nd and 4th hours. The IL-6 and TNF-alpha expression decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the LPS group in the 2nd and 4th hours. The 5-HT7 receptor mRNA expression increased in the LPS group when compared to the healthy group in the 2nd hour. The 5-HT7 receptor mRNA expression decreased in the LPS + AGO and LPS + AGO + PARA groups when compared to the LPS group in the 2nd hour. The 5-HT7 receptor mRNA expression increased the in LPS + ANTA and LPS + ANTA + PARA groups when compared to the LPS group in the 2nd hour. Conclusion The 5-HT7 receptor is a potential defense mechanism in stopping fever and the antipyretic property of paracetamol is not due to the 5-HT7 receptor.", 
  "headline": "The investigation of possible roles of central 5-HT7 receptors in antipyretic effect mechanism of paracetamol in LPS-induced hyperthermia model of mice", 
  "identifier": 73699, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The investigation of possible roles of central 5-HT7 receptors in antipyretic effect mechanism of paracetamol in LPS-induced hyperthermia model of mice", 
  "url": "https://aperta.ulakbim.gov.tr/record/73699"
}