1 Ocak 2019 Dergi makalesi Açık Erişim

Kose, Duygu; Cadirci, Elif; Halici, Zekai; Sirin, Busra; Dincer, Busra

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/73699</identifier>
  <creators>
    <creator>
      <creatorName>Kose, Duygu</creatorName>
      <givenName>Duygu</givenName>
      <familyName>Kose</familyName>
      <affiliation>Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cadirci, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Cadirci</familyName>
      <affiliation>Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Halici, Zekai</creatorName>
      <givenName>Zekai</givenName>
      <familyName>Halici</familyName>
      <affiliation>Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sirin, Busra</creatorName>
      <givenName>Busra</givenName>
      <familyName>Sirin</familyName>
      <affiliation>Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dincer, Busra</creatorName>
      <givenName>Busra</givenName>
      <familyName>Dincer</familyName>
      <affiliation>Binali Yildirim Univ, Dept Pharmacol, Fac Pharm, TR-24100 Erzincan, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Investigation Of Possible Roles Of Central 5-Ht7 Receptors In Antipyretic Effect Mechanism Of Paracetamol In Lps-Induced Hyperthermia Model Of Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/73699</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10787-019-00617-1</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Aim This study aimed to investigate the role of the 5-HT7 receptor in fever mechanisms and its possible effect on the antipyretic mechanism of paracetamol. Materials and methods The study consisted of eight experimental groups and one control group. Group I: healthy, II: LPS, III: LPS + PARA, IV: LPS + AGO, V: LPS + ANTA, VI: LPS + AGO + ANTA, VII: LPS + AGO + PARA, VIII: LPS + ANTA + PARA, and IX: LPS + AGO + ANTA + PARA. Rectal temperatures were measured with a rectal thermometer. At the end of the experiment, tissues were examined molecularly. Real-time PCR mRNA expression analyses were performed for the 5-HT7 receptor, IL-6, and TNF-alpha in hypothalamus tissue. Results The mean differences in rectal temperature increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group and decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the healthy group. The IL-6 and TNF-alpha mRNA expression increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group in the 2nd and 4th hours. The IL-6 and TNF-alpha expression decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the LPS group in the 2nd and 4th hours. The 5-HT7 receptor mRNA expression increased in the LPS group when compared to the healthy group in the 2nd hour. The 5-HT7 receptor mRNA expression decreased in the LPS + AGO and LPS + AGO + PARA groups when compared to the LPS group in the 2nd hour. The 5-HT7 receptor mRNA expression increased the in LPS + ANTA and LPS + ANTA + PARA groups when compared to the LPS group in the 2nd hour. Conclusion The 5-HT7 receptor is a potential defense mechanism in stopping fever and the antipyretic property of paracetamol is not due to the 5-HT7 receptor.</description>
  </descriptions>
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