1 Ocak 2019 Dergi makalesi Açık Erişim

Kose, Duygu; Cadirci, Elif; Halici, Zekai; Sirin, Busra; Dincer, Busra

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  "doi": "10.1007/s10787-019-00617-1", 
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    "communities": [
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        "id": "tubitak-destekli-proje-yayinlari"
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    "creators": [
      {
        "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
        "name": "Kose, Duygu"
      }, 
      {
        "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
        "name": "Cadirci, Elif"
      }, 
      {
        "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
        "name": "Halici, Zekai"
      }, 
      {
        "affiliation": "Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey", 
        "name": "Sirin, Busra"
      }, 
      {
        "affiliation": "Binali Yildirim Univ, Dept Pharmacol, Fac Pharm, TR-24100 Erzincan, Turkey", 
        "name": "Dincer, Busra"
      }
    ], 
    "description": "Aim This study aimed to investigate the role of the 5-HT7 receptor in fever mechanisms and its possible effect on the antipyretic mechanism of paracetamol. Materials and methods The study consisted of eight experimental groups and one control group. Group I: healthy, II: LPS, III: LPS + PARA, IV: LPS + AGO, V: LPS + ANTA, VI: LPS + AGO + ANTA, VII: LPS + AGO + PARA, VIII: LPS + ANTA + PARA, and IX: LPS + AGO + ANTA + PARA. Rectal temperatures were measured with a rectal thermometer. At the end of the experiment, tissues were examined molecularly. Real-time PCR mRNA expression analyses were performed for the 5-HT7 receptor, IL-6, and TNF-alpha in hypothalamus tissue. Results The mean differences in rectal temperature increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group and decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the healthy group. The IL-6 and TNF-alpha mRNA expression increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group in the 2nd and 4th hours. The IL-6 and TNF-alpha expression decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the LPS group in the 2nd and 4th hours. The 5-HT7 receptor mRNA expression increased in the LPS group when compared to the healthy group in the 2nd hour. The 5-HT7 receptor mRNA expression decreased in the LPS + AGO and LPS + AGO + PARA groups when compared to the LPS group in the 2nd hour. The 5-HT7 receptor mRNA expression increased the in LPS + ANTA and LPS + ANTA + PARA groups when compared to the LPS group in the 2nd hour. Conclusion The 5-HT7 receptor is a potential defense mechanism in stopping fever and the antipyretic property of paracetamol is not due to the 5-HT7 receptor.", 
    "doi": "10.1007/s10787-019-00617-1", 
    "has_grant": false, 
    "journal": {
      "issue": "6", 
      "pages": "1169-1178", 
      "title": "INFLAMMOPHARMACOLOGY", 
      "volume": "27"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "The investigation of possible roles of central 5-HT7 receptors in antipyretic effect mechanism of paracetamol in LPS-induced hyperthermia model of mice"
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