1 Ocak 2019 Dergi makalesi Açık Erişim

Kose, Duygu; Cadirci, Elif; Halici, Zekai; Sirin, Busra; Dincer, Busra

Citation Style Language JSON

{
  "DOI": "10.1007/s10787-019-00617-1", 
  "abstract": "Aim This study aimed to investigate the role of the 5-HT7 receptor in fever mechanisms and its possible effect on the antipyretic mechanism of paracetamol. Materials and methods The study consisted of eight experimental groups and one control group. Group I: healthy, II: LPS, III: LPS + PARA, IV: LPS + AGO, V: LPS + ANTA, VI: LPS + AGO + ANTA, VII: LPS + AGO + PARA, VIII: LPS + ANTA + PARA, and IX: LPS + AGO + ANTA + PARA. Rectal temperatures were measured with a rectal thermometer. At the end of the experiment, tissues were examined molecularly. Real-time PCR mRNA expression analyses were performed for the 5-HT7 receptor, IL-6, and TNF-alpha in hypothalamus tissue. Results The mean differences in rectal temperature increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group and decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the healthy group. The IL-6 and TNF-alpha mRNA expression increased in the LPS, LPS + ANTA, and LPS + AGO + ANTA groups when compared to the healthy group in the 2nd and 4th hours. The IL-6 and TNF-alpha expression decreased in the LPS + PARA, LPS + AGO, LPS + AGO + PARA, and LPS + AGO + ANTA + PARA groups when compared to the LPS group in the 2nd and 4th hours. The 5-HT7 receptor mRNA expression increased in the LPS group when compared to the healthy group in the 2nd hour. The 5-HT7 receptor mRNA expression decreased in the LPS + AGO and LPS + AGO + PARA groups when compared to the LPS group in the 2nd hour. The 5-HT7 receptor mRNA expression increased the in LPS + ANTA and LPS + ANTA + PARA groups when compared to the LPS group in the 2nd hour. Conclusion The 5-HT7 receptor is a potential defense mechanism in stopping fever and the antipyretic property of paracetamol is not due to the 5-HT7 receptor.", 
  "author": [
    {
      "family": "Kose", 
      "given": " Duygu"
    }, 
    {
      "family": "Cadirci", 
      "given": " Elif"
    }, 
    {
      "family": "Halici", 
      "given": " Zekai"
    }, 
    {
      "family": "Sirin", 
      "given": " Busra"
    }, 
    {
      "family": "Dincer", 
      "given": " Busra"
    }
  ], 
  "container_title": "INFLAMMOPHARMACOLOGY", 
  "id": "73699", 
  "issue": "6", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1169-1178", 
  "title": "The investigation of possible roles of central 5-HT7 receptors in antipyretic effect mechanism of paracetamol in LPS-induced hyperthermia model of mice", 
  "type": "article-journal", 
  "volume": "27"
}