Dergi makalesi Açık Erişim
Isiklan, Nuran; Altinisik, Zeynep
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:72217</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS</subfield> <subfield code="v">575</subfield> <subfield code="c">352-362</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2019-01-01</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.colsurfa.2019.05.013</subfield> <subfield code="2">doi</subfield> </datafield> <controlfield tag="001">72217</controlfield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Isiklan, Nuran</subfield> <subfield code="u">Kirikkale Univ, Fac Arts & Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/72217/files/bib-d16e8a32-7d38-4bc3-868b-cd566b1b9721.txt</subfield> <subfield code="s">233</subfield> <subfield code="z">md5:ad56b890d5b6ac22db5c8e49769a8b6f</subfield> </datafield> <controlfield tag="005">20210316034009.0</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Altinisik, Zeynep</subfield> <subfield code="u">Kirikkale Univ, Fac Arts & Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> </record>
Görüntülenme | 77 |
İndirme | 9 |
Veri hacmi | 2.1 kB |
Tekil görüntülenme | 72 |
Tekil indirme | 9 |