Dergi makalesi Açık Erişim
Isiklan, Nuran; Altinisik, Zeynep
{ "@context": "https://schema.org/", "@id": 72217, "@type": "ScholarlyArticle", "creator": [ { "@type": "Person", "affiliation": "Kirikkale Univ, Fac Arts & Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey", "name": "Isiklan, Nuran" }, { "@type": "Person", "affiliation": "Kirikkale Univ, Fac Arts & Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey", "name": "Altinisik, Zeynep" } ], "datePublished": "2019-01-01", "description": "Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.", "headline": "Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles", "identifier": 72217, "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", "license": "http://www.opendefinition.org/licenses/cc-by", "name": "Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles", "url": "https://aperta.ulakbim.gov.tr/record/72217" }
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