1 Ocak 2019 Dergi makalesi Açık Erişim

Isiklan, Nuran; Altinisik, Zeynep

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/72217</identifier>
  <creators>
    <creator>
      <creatorName>Isiklan, Nuran</creatorName>
      <givenName>Nuran</givenName>
      <familyName>Isiklan</familyName>
      <affiliation>Kirikkale Univ, Fac Arts &amp; Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Altinisik, Zeynep</creatorName>
      <givenName>Zeynep</givenName>
      <familyName>Altinisik</familyName>
      <affiliation>Kirikkale Univ, Fac Arts &amp; Sci, Dept Chem, TR-71450 Yahsihan, Kirikkale, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Development And Characterization Of Dual Sensitive Poly(N,N-Diethyl Acrylamide) Grafted Alginate Microparticles</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/72217</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.colsurfa.2019.05.013</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.</description>
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