1 Ocak 2019 Dergi makalesi Açık Erişim

Isiklan, Nuran; Altinisik, Zeynep

Citation Style Language JSON

{
  "DOI": "10.1016/j.colsurfa.2019.05.013", 
  "abstract": "Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.", 
  "author": [
    {
      "family": "Isiklan", 
      "given": " Nuran"
    }, 
    {
      "family": "Altinisik", 
      "given": " Zeynep"
    }
  ], 
  "container_title": "COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS", 
  "id": "72217", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "352-362", 
  "title": "Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles", 
  "type": "article-journal", 
  "volume": "575"
}