1 Ocak 2019 Dergi makalesi Açık Erişim

Bugan, Ilknur; Kucuk, Selma; Karagoz, Zeynep; Fraser, Scott P.; Kaya, Handan; Dodson, Andrew; Foster, Christopher S.; Altun, Seyhan; Djamgoz, Mustafa B. A.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/71757</identifier>
  <creators>
    <creator>
      <creatorName>Bugan, Ilknur</creatorName>
      <givenName>Ilknur</givenName>
      <familyName>Bugan</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kucuk, Selma</creatorName>
      <givenName>Selma</givenName>
      <familyName>Kucuk</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karagoz, Zeynep</creatorName>
      <givenName>Zeynep</givenName>
      <familyName>Karagoz</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Fraser, Scott P.</creatorName>
      <givenName>Scott P.</givenName>
      <familyName>Fraser</familyName>
      <affiliation>Imperial Coll London, Dept Life Sci, Sir Alexander Fleming Bldg, London SW7 2AZ, England</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya, Handan</creatorName>
      <givenName>Handan</givenName>
      <familyName>Kaya</familyName>
      <affiliation>Marmara Univ, Dept Pathol, Sch Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dodson, Andrew</creatorName>
      <givenName>Andrew</givenName>
      <familyName>Dodson</familyName>
      <affiliation>Inst Canc Res, Fulham Rd, London SW3 6JB, England</affiliation>
    </creator>
    <creator>
      <creatorName>Foster, Christopher S.</creatorName>
      <givenName>Christopher S.</givenName>
      <familyName>Foster</familyName>
      <affiliation>HCA Healthcare UK, Cellular Pathol Labs, GPS House,215 Great Portland St, London W1W 5PN, England</affiliation>
    </creator>
    <creator>
      <creatorName>Altun, Seyhan</creatorName>
      <givenName>Seyhan</givenName>
      <familyName>Altun</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Djamgoz, Mustafa B. A.</creatorName>
      <givenName>Mustafa B. A.</givenName>
      <familyName>Djamgoz</familyName>
    </creator>
  </creators>
  <titles>
    <title>Anti-Metastatic Effect Of Ranolazine In An In Vivo Rat Model Of Prostate Cancer, And Expression Of Voltage-Gated Sodium Channel Protein In Human Prostate</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/71757</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/s41391-019-0128-3</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.</description>
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