1 Ocak 2019 Dergi makalesi Açık Erişim

Kaymaz, Aylin Pak; Acaroglu-Degitz, Ilayda; Yapaoz, Melda Altikatoglu; Sezer, Ali Demir; Malta, Seyda; Aksu, Burak; Eren, Tarik

Dublin Core

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  <dc:creator>Kaymaz, Aylin Pak</dc:creator>
  <dc:creator>Acaroglu-Degitz, Ilayda</dc:creator>
  <dc:creator>Yapaoz, Melda Altikatoglu</dc:creator>
  <dc:creator>Sezer, Ali Demir</dc:creator>
  <dc:creator>Malta, Seyda</dc:creator>
  <dc:creator>Aksu, Burak</dc:creator>
  <dc:creator>Eren, Tarik</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>This paper focuses on the synthesis of cationic antibacterial polymers that could be a potential source for new-generation antibiotics with well-defined architecture derived from the Ring Opening Metathesis Polymerization (ROMP) technique. Mono- and double-charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10,000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, &gt;= 1000 mu g/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed that the double-charge bearing polymers have the highest antimicrobial activity (S. aureus= 8 mu g/mL) and a high selectivity against S. aureus (&gt;250). Percent killing efficiencies were tested on a glass surface where moderate killing efficiency was observed in the range of 40-80% in 5 min. Cationic charge density and zeta potential studies were used to investigate the mechanisms of antimicrobial efficiency of the polymers in a solution during the action against S. aureus to understand structure-activity relationships. Scanning electron microscopy (SEM) was also conducted for the bacterial morphology assay.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/68227</dc:identifier>
  <dc:identifier>oai:zenodo.org:68227</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MATERIALIA 5</dc:source>
  <dc:title>Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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