1 Ocak 2019 Dergi makalesi Açık Erişim

Kaymaz, Aylin Pak; Acaroglu-Degitz, Ilayda; Yapaoz, Melda Altikatoglu; Sezer, Ali Demir; Malta, Seyda; Aksu, Burak; Eren, Tarik

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/68227</identifier>
  <creators>
    <creator>
      <creatorName>Kaymaz, Aylin Pak</creatorName>
      <givenName>Aylin Pak</givenName>
      <familyName>Kaymaz</familyName>
      <affiliation>Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Acaroglu-Degitz, Ilayda</creatorName>
      <givenName>Ilayda</givenName>
      <familyName>Acaroglu-Degitz</familyName>
      <affiliation>Yeditepe Univ, Dept Chem Engn, Kayisdagi Cd 326A, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yapaoz, Melda Altikatoglu</creatorName>
      <givenName>Melda Altikatoglu</givenName>
      <familyName>Yapaoz</familyName>
      <affiliation>Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sezer, Ali Demir</creatorName>
      <givenName>Ali Demir</givenName>
      <familyName>Sezer</familyName>
      <affiliation>Marmara Univ, Dept Pharm, Tibbiye Cad 49, TR-34668 Uskudar Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Malta, Seyda</creatorName>
      <givenName>Seyda</givenName>
      <familyName>Malta</familyName>
      <affiliation>Yeditepe Univ, Dept Chem Engn, Kayisdagi Cd 326A, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aksu, Burak</creatorName>
      <givenName>Burak</givenName>
      <familyName>Aksu</familyName>
      <affiliation>Marmara Univ, Dept Med Microbiol, Maltepe Basibuyuk Yolu Sok 9-2, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Eren, Tarik</creatorName>
      <givenName>Tarik</givenName>
      <familyName>Eren</familyName>
      <affiliation>Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of 1,4-Diazabicyclo[2.2.2]Octane And Pyridinium Based Cationic Polymers Via Romp Technique And Examination Of Their Antibacterial Activity And Cytotoxicity</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/68227</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.mtla.2019.100246</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">This paper focuses on the synthesis of cationic antibacterial polymers that could be a potential source for new-generation antibiotics with well-defined architecture derived from the Ring Opening Metathesis Polymerization (ROMP) technique. Mono- and double-charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10,000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, &amp;gt;= 1000 mu g/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed that the double-charge bearing polymers have the highest antimicrobial activity (S. aureus= 8 mu g/mL) and a high selectivity against S. aureus (&amp;gt;250). Percent killing efficiencies were tested on a glass surface where moderate killing efficiency was observed in the range of 40-80% in 5 min. Cationic charge density and zeta potential studies were used to investigate the mechanisms of antimicrobial efficiency of the polymers in a solution during the action against S. aureus to understand structure-activity relationships. Scanning electron microscopy (SEM) was also conducted for the bacterial morphology assay.</description>
  </descriptions>
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