1 Ocak 2019 Dergi makalesi Açık Erişim

Kaymaz, Aylin Pak; Acaroglu-Degitz, Ilayda; Yapaoz, Melda Altikatoglu; Sezer, Ali Demir; Malta, Seyda; Aksu, Burak; Eren, Tarik

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{
  "@context": "https://schema.org/", 
  "@id": 68227, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey", 
      "name": "Kaymaz, Aylin Pak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Dept Chem Engn, Kayisdagi Cd 326A, TR-34755 Istanbul, Turkey", 
      "name": "Acaroglu-Degitz, Ilayda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey", 
      "name": "Yapaoz, Melda Altikatoglu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Dept Pharm, Tibbiye Cad 49, TR-34668 Uskudar Istanbul, Turkey", 
      "name": "Sezer, Ali Demir"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Dept Chem Engn, Kayisdagi Cd 326A, TR-34755 Istanbul, Turkey", 
      "name": "Malta, Seyda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Dept Med Microbiol, Maltepe Basibuyuk Yolu Sok 9-2, Istanbul, Turkey", 
      "name": "Aksu, Burak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yildiz Tech Univ, Dept Chem, Davutpqa Kampusu, TR-34220 Esenler, Turkey", 
      "name": "Eren, Tarik"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "This paper focuses on the synthesis of cationic antibacterial polymers that could be a potential source for new-generation antibiotics with well-defined architecture derived from the Ring Opening Metathesis Polymerization (ROMP) technique. Mono- and double-charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10,000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, >= 1000 mu g/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed that the double-charge bearing polymers have the highest antimicrobial activity (S. aureus= 8 mu g/mL) and a high selectivity against S. aureus (>250). Percent killing efficiencies were tested on a glass surface where moderate killing efficiency was observed in the range of 40-80% in 5 min. Cationic charge density and zeta potential studies were used to investigate the mechanisms of antimicrobial efficiency of the polymers in a solution during the action against S. aureus to understand structure-activity relationships. Scanning electron microscopy (SEM) was also conducted for the bacterial morphology assay.", 
  "headline": "Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity", 
  "identifier": 68227, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity", 
  "url": "https://aperta.ulakbim.gov.tr/record/68227"
}