1 Ocak 2019 Dergi makalesi Açık Erişim

Kaymaz, Aylin Pak; Acaroglu-Degitz, Ilayda; Yapaoz, Melda Altikatoglu; Sezer, Ali Demir; Malta, Seyda; Aksu, Burak; Eren, Tarik

Citation Style Language JSON

{
  "DOI": "10.1016/j.mtla.2019.100246", 
  "abstract": "This paper focuses on the synthesis of cationic antibacterial polymers that could be a potential source for new-generation antibiotics with well-defined architecture derived from the Ring Opening Metathesis Polymerization (ROMP) technique. Mono- and double-charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10,000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, >= 1000 mu g/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed that the double-charge bearing polymers have the highest antimicrobial activity (S. aureus= 8 mu g/mL) and a high selectivity against S. aureus (>250). Percent killing efficiencies were tested on a glass surface where moderate killing efficiency was observed in the range of 40-80% in 5 min. Cationic charge density and zeta potential studies were used to investigate the mechanisms of antimicrobial efficiency of the polymers in a solution during the action against S. aureus to understand structure-activity relationships. Scanning electron microscopy (SEM) was also conducted for the bacterial morphology assay.", 
  "author": [
    {
      "family": "Kaymaz", 
      "given": " Aylin Pak"
    }, 
    {
      "family": "Acaroglu-Degitz", 
      "given": " Ilayda"
    }, 
    {
      "family": "Yapaoz", 
      "given": " Melda Altikatoglu"
    }, 
    {
      "family": "Sezer", 
      "given": " Ali Demir"
    }, 
    {
      "family": "Malta", 
      "given": " Seyda"
    }, 
    {
      "family": "Aksu", 
      "given": " Burak"
    }, 
    {
      "family": "Eren", 
      "given": " Tarik"
    }
  ], 
  "container_title": "MATERIALIA", 
  "id": "68227", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP technique and examination of their antibacterial activity and cytotoxicity", 
  "type": "article-journal", 
  "volume": "5"
}