1 Ocak 2014 Dergi makalesi Açık Erişim

Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, Dinc

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Sozmen, Mahmut</dc:creator>
  <dc:creator>Devrim, Alparslan Kadir</dc:creator>
  <dc:creator>Tunca, Recai</dc:creator>
  <dc:creator>Bayezit, Murat</dc:creator>
  <dc:creator>Dag, Serpil</dc:creator>
  <dc:creator>Essiz, Dinc</dc:creator>
  <dc:date>2014-01-01</dc:date>
  <dc:description>The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p &lt; 0.0001) the apoptotic rate. FB1 administration significantly increased (p &lt; 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p &lt; 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p &lt; 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p &lt; 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/63215</dc:identifier>
  <dc:identifier>oai:zenodo.org:63215</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF VETERINARY SCIENCE 15(1) 51-60</dc:source>
  <dc:title>Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>