1 Ocak 2014 Dergi makalesi Açık Erişim

Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, Dinc

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/63215</identifier>
  <creators>
    <creator>
      <creatorName>Sozmen, Mahmut</creatorName>
      <givenName>Mahmut</givenName>
      <familyName>Sozmen</familyName>
    </creator>
    <creator>
      <creatorName>Devrim, Alparslan Kadir</creatorName>
      <givenName>Alparslan Kadir</givenName>
      <familyName>Devrim</familyName>
      <affiliation>Univ Mehmet Akif Ersoy, Fac Vet Med, Dept Biochem, TR-15100 Burdur, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunca, Recai</creatorName>
      <givenName>Recai</givenName>
      <familyName>Tunca</familyName>
      <affiliation>Adnan Menderes Univ, Fac Vet Med, Dept Pathol, TR-09010 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bayezit, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Bayezit</familyName>
      <affiliation>Univ Mehmet Akif Ersoy, Fac Vet Med, Dept Pharmacol &amp; Toxicol, TR-15100 Burdur, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dag, Serpil</creatorName>
      <givenName>Serpil</givenName>
      <familyName>Dag</familyName>
      <affiliation>Kafkas Univ, Fac Vet Med, Dept Pathol, TR-36100 Kars, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Essiz, Dinc</creatorName>
      <givenName>Dinc</givenName>
      <familyName>Essiz</familyName>
      <affiliation>Kirikkale Univ, Fac Vet Med, Dept Pharmacol &amp; Toxicol, TR-71450 Kirikkale, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Protective Effects Of Silymarin On Fumonisin B-1-Induced Hepatotoxicity In Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/63215</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.4142/jvs.2014.15.1.51</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p &amp;lt; 0.0001) the apoptotic rate. FB1 administration significantly increased (p &amp;lt; 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p &amp;lt; 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p &amp;lt; 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p &amp;lt; 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.</description>
  </descriptions>
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