1 Ocak 2014 Dergi makalesi Açık Erişim

Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, Dinc

Citation Style Language JSON

{
  "DOI": "10.4142/jvs.2014.15.1.51", 
  "abstract": "The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.", 
  "author": [
    {
      "family": "Sozmen", 
      "given": " Mahmut"
    }, 
    {
      "family": "Devrim", 
      "given": " Alparslan Kadir"
    }, 
    {
      "family": "Tunca", 
      "given": " Recai"
    }, 
    {
      "family": "Bayezit", 
      "given": " Murat"
    }, 
    {
      "family": "Dag", 
      "given": " Serpil"
    }, 
    {
      "family": "Essiz", 
      "given": " Dinc"
    }
  ], 
  "container_title": "JOURNAL OF VETERINARY SCIENCE", 
  "id": "63215", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2014, 
        1, 
        1
      ]
    ]
  }, 
  "page": "51-60", 
  "title": "Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice", 
  "type": "article-journal", 
  "volume": "15"
}