1 Ocak 2014 Dergi makalesi Açık Erişim

Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, Dinc

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    "creators": [
      {
        "name": "Sozmen, Mahmut"
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      {
        "affiliation": "Univ Mehmet Akif Ersoy, Fac Vet Med, Dept Biochem, TR-15100 Burdur, Turkey", 
        "name": "Devrim, Alparslan Kadir"
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      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Pathol, TR-09010 Aydin, Turkey", 
        "name": "Tunca, Recai"
      }, 
      {
        "affiliation": "Univ Mehmet Akif Ersoy, Fac Vet Med, Dept Pharmacol & Toxicol, TR-15100 Burdur, Turkey", 
        "name": "Bayezit, Murat"
      }, 
      {
        "affiliation": "Kafkas Univ, Fac Vet Med, Dept Pathol, TR-36100 Kars, Turkey", 
        "name": "Dag, Serpil"
      }, 
      {
        "affiliation": "Kirikkale Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-71450 Kirikkale, Turkey", 
        "name": "Essiz, Dinc"
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    "description": "The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.", 
    "doi": "10.4142/jvs.2014.15.1.51", 
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    "journal": {
      "issue": "1", 
      "pages": "51-60", 
      "title": "JOURNAL OF VETERINARY SCIENCE", 
      "volume": "15"
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    "publication_date": "2014-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
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    "title": "Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice"
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