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Synthesis of amino-cyclobutanes via [2+2] cycloadditions involving keteniminium intermediates

Kolleth, Amandine; Lumbroso, Alexandre; Tanriver, Gamze; Catak, Saron; Sulzer-Mosse, Sarah; De Mesmaeker, Alain


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        "name": "Kolleth, Amandine"
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      {
        "affiliation": "Syngenta Crop Protect AG, Crop Protect Res, Res Chem, Schaffhauserstr 101, CH-4332 Basel, Switzerland", 
        "name": "Lumbroso, Alexandre"
      }, 
      {
        "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
        "name": "Tanriver, Gamze"
      }, 
      {
        "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
        "name": "Catak, Saron"
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        "affiliation": "Syngenta Crop Protect AG, Crop Protect Res, Res Chem, Schaffhauserstr 101, CH-4332 Basel, Switzerland", 
        "name": "Sulzer-Mosse, Sarah"
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        "name": "De Mesmaeker, Alain"
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    "description": "We describe an efficient method for the synthesis of aminocyclobutanes via a [2 + 2] cycloaddition between a keteniminium salt and an alkene, followed by a reduction step. The use of easily removable N-allyl moieties as protecting groups increases the potential of this method to access, in a few steps, highly functionalized cyclobutaneamine-containing building blocks. Moreover, DFT calculations verify the compatibility of N-allyl and N-propargyl keteniminiums in [2 + 2] cycloaddition reactions. (C) 2016 Elsevier Ltd. All rights reserved.", 
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