1 Ocak 2016 Dergi makalesi Açık Erişim

Erson-Bensan, Ayse Elif

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  <dc:creator>Erson-Bensan, Ayse Elif</dc:creator>
  <dc:date>2016-01-01</dc:date>
  <dc:description>Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/54461</dc:identifier>
  <dc:identifier>oai:zenodo.org:54461</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF MOLECULAR ENDOCRINOLOGY 57(2) F29-F34</dc:source>
  <dc:title>Alternative polyadenylation and RNA-binding proteins</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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