1 Ocak 2016 Dergi makalesi Açık Erişim

Erson-Bensan, Ayse Elif

Citation Style Language JSON

{
  "DOI": "10.1530/JME-16-0070", 
  "abstract": "Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches.", 
  "author": [
    {
      "family": "Erson-Bensan", 
      "given": " Ayse Elif"
    }
  ], 
  "container_title": "JOURNAL OF MOLECULAR ENDOCRINOLOGY", 
  "id": "54461", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "F29-F34", 
  "title": "Alternative polyadenylation and RNA-binding proteins", 
  "type": "article-journal", 
  "volume": "57"
}