1 Ocak 2016 Dergi makalesi Açık Erişim

Erson-Bensan, Ayse Elif

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{
  "@context": "https://schema.org/", 
  "@id": 54461, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Univ Mahallesi, Orta Dogu Tekn Univ ODTU METU, Dept Biol Sci, Ankara, Turkey", 
      "name": "Erson-Bensan, Ayse Elif"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches.", 
  "headline": "Alternative polyadenylation and RNA-binding proteins", 
  "identifier": 54461, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Alternative polyadenylation and RNA-binding proteins", 
  "url": "https://aperta.ulakbim.gov.tr/record/54461"
}