1 Ocak 2016 Dergi makalesi Açık Erişim

Erson-Bensan, Ayse Elif

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        "affiliation": "Univ Mahallesi, Orta Dogu Tekn Univ ODTU METU, Dept Biol Sci, Ankara, Turkey", 
        "name": "Erson-Bensan, Ayse Elif"
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    "description": "Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches.", 
    "doi": "10.1530/JME-16-0070", 
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    "journal": {
      "issue": "2", 
      "pages": "F29-F34", 
      "title": "JOURNAL OF MOLECULAR ENDOCRINOLOGY", 
      "volume": "57"
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    "publication_date": "2016-01-01", 
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    "title": "Alternative polyadenylation and RNA-binding proteins"
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