1 Ocak 2017 Dergi makalesi Açık Erişim

Aytac, Zeynep; Yildiz, Zehra Irem; Kayaci-Senirmak, Fatma; Tekinay, Turgay; Uyar, Tamer

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  "@id": 49911, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Aytac, Zeynep"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Yildiz, Zehra Irem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Kayaci-Senirmak, Fatma"
    }, 
    {
      "@type": "Person", 
      "name": "Tekinay, Turgay"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Uyar, Tamer"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HP beta CD, M beta CD, and HP gamma CD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45-89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool. (C) 2017 Elsevier Ltd. All rights reserved.", 
  "headline": "Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity", 
  "identifier": 49911, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity", 
  "url": "https://aperta.ulakbim.gov.tr/record/49911"
}