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Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity

Aytac, Zeynep; Yildiz, Zehra Irem; Kayaci-Senirmak, Fatma; Tekinay, Turgay; Uyar, Tamer


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{
  "DOI": "10.1016/j.foodchem.2017.03.113", 
  "abstract": "The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HP beta CD, M beta CD, and HP gamma CD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45-89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool. (C) 2017 Elsevier Ltd. All rights reserved.", 
  "author": [
    {
      "family": "Aytac", 
      "given": " Zeynep"
    }, 
    {
      "family": "Yildiz", 
      "given": " Zehra Irem"
    }, 
    {
      "family": "Kayaci-Senirmak", 
      "given": " Fatma"
    }, 
    {
      "family": "Tekinay", 
      "given": " Turgay"
    }, 
    {
      "family": "Uyar", 
      "given": " Tamer"
    }
  ], 
  "container_title": "FOOD CHEMISTRY", 
  "id": "49911", 
  "issued": {
    "date-parts": [
      [
        2017, 
        1, 
        1
      ]
    ]
  }, 
  "page": "192-201", 
  "title": "Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity", 
  "type": "article-journal", 
  "volume": "231"
}
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