1 Ocak 2017 Dergi makalesi Açık Erişim

Turgut, I. Meric; Keskin, E.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/49531</identifier>
  <creators>
    <creator>
      <creatorName>Turgut, I. Meric</creatorName>
      <givenName>I. Meric</givenName>
      <familyName>Turgut</familyName>
      <affiliation>Ankara Univ, Dept Fisheries &amp; Aquaculture Engn, Fac Agr, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Keskin, E.</creatorName>
      <givenName>E.</givenName>
      <familyName>Keskin</familyName>
      <affiliation>Ankara Univ, Dept Fisheries &amp; Aquaculture Engn, Fac Agr, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Risk Assessment Of A Formamidine Pesticide, Amitraz, Focusing On Thyroid Hormone Receptors (Trs) In Rainbow Trout, Oncorhynchus Mykiss</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/49531</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.14715/cmb/2017.63.9.6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Amitraz, a formamidine pesticide, and their metabolites have the potential to disrupt endocrine homeostasis in a variety of organisms, nevertheless there is a lack of information concerning such effects and underlying mechanisms in any fish species. To evaluate the potential impacts of Trasil (EC; active constituent 200 g amitraz/L), a commercial product of amitraz, on thyroid hormone (TH) homeostasis of rainbow trout (Oncorhynchus mykiss); mRNA levels of thyroid hormone receptors (TRs), TR alpha and TR beta, were determined by RT-PCR soon after sub-lethal administration in a static bio-assay system. The sub-lethal exposure of 0.84 mg/L amitraz resulted in upregulation of both TR alpha and TR beta genes for muscle and liver, respectively in a tissue-manner, though the differences were found statistically insignificant (P&amp;gt;0.05). The present results emerged an endocrine interaction between amitraz based formulation and TH homeostasis, but still needs further detail studies to a better understanding of TH mechanism in teleosts in response to environmental compounds.</description>
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