1 Ocak 2017 Dergi makalesi Açık Erişim

Turgut, I. Meric; Keskin, E.

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{
  "@context": "https://schema.org/", 
  "@id": 49531, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Dept Fisheries & Aquaculture Engn, Fac Agr, Ankara, Turkey", 
      "name": "Turgut, I. Meric"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Dept Fisheries & Aquaculture Engn, Fac Agr, Ankara, Turkey", 
      "name": "Keskin, E."
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Amitraz, a formamidine pesticide, and their metabolites have the potential to disrupt endocrine homeostasis in a variety of organisms, nevertheless there is a lack of information concerning such effects and underlying mechanisms in any fish species. To evaluate the potential impacts of Trasil (EC; active constituent 200 g amitraz/L), a commercial product of amitraz, on thyroid hormone (TH) homeostasis of rainbow trout (Oncorhynchus mykiss); mRNA levels of thyroid hormone receptors (TRs), TR alpha and TR beta, were determined by RT-PCR soon after sub-lethal administration in a static bio-assay system. The sub-lethal exposure of 0.84 mg/L amitraz resulted in upregulation of both TR alpha and TR beta genes for muscle and liver, respectively in a tissue-manner, though the differences were found statistically insignificant (P>0.05). The present results emerged an endocrine interaction between amitraz based formulation and TH homeostasis, but still needs further detail studies to a better understanding of TH mechanism in teleosts in response to environmental compounds.", 
  "headline": "Risk assessment of a formamidine pesticide, Amitraz, focusing on thyroid hormone receptors (TRs) in rainbow trout, Oncorhynchus mykiss", 
  "identifier": 49531, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Risk assessment of a formamidine pesticide, Amitraz, focusing on thyroid hormone receptors (TRs) in rainbow trout, Oncorhynchus mykiss", 
  "url": "https://aperta.ulakbim.gov.tr/record/49531"
}