1 Ocak 2017 Dergi makalesi Açık Erişim

Turgut, I. Meric; Keskin, E.

Citation Style Language JSON

{
  "DOI": "10.14715/cmb/2017.63.9.6", 
  "abstract": "Amitraz, a formamidine pesticide, and their metabolites have the potential to disrupt endocrine homeostasis in a variety of organisms, nevertheless there is a lack of information concerning such effects and underlying mechanisms in any fish species. To evaluate the potential impacts of Trasil (EC; active constituent 200 g amitraz/L), a commercial product of amitraz, on thyroid hormone (TH) homeostasis of rainbow trout (Oncorhynchus mykiss); mRNA levels of thyroid hormone receptors (TRs), TR alpha and TR beta, were determined by RT-PCR soon after sub-lethal administration in a static bio-assay system. The sub-lethal exposure of 0.84 mg/L amitraz resulted in upregulation of both TR alpha and TR beta genes for muscle and liver, respectively in a tissue-manner, though the differences were found statistically insignificant (P>0.05). The present results emerged an endocrine interaction between amitraz based formulation and TH homeostasis, but still needs further detail studies to a better understanding of TH mechanism in teleosts in response to environmental compounds.", 
  "author": [
    {
      "family": "Turgut", 
      "given": " I. Meric"
    }, 
    {
      "family": "Keskin", 
      "given": " E."
    }
  ], 
  "container_title": "CELLULAR AND MOLECULAR BIOLOGY", 
  "id": "49531", 
  "issue": "9", 
  "issued": {
    "date-parts": [
      [
        2017, 
        1, 
        1
      ]
    ]
  }, 
  "page": "29-34", 
  "title": "Risk assessment of a formamidine pesticide, Amitraz, focusing on thyroid hormone receptors (TRs) in rainbow trout, Oncorhynchus mykiss", 
  "type": "article-journal", 
  "volume": "63"
}