1 Ocak 2017 Dergi makalesi Açık Erişim

Turgut, I. Meric; Keskin, E.

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    <subfield code="a">Risk assessment of a formamidine pesticide, Amitraz, focusing on thyroid hormone receptors (TRs) in rainbow trout, Oncorhynchus mykiss</subfield>
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    <subfield code="a">Amitraz, a formamidine pesticide, and their metabolites have the potential to disrupt endocrine homeostasis in a variety of organisms, nevertheless there is a lack of information concerning such effects and underlying mechanisms in any fish species. To evaluate the potential impacts of Trasil (EC; active constituent 200 g amitraz/L), a commercial product of amitraz, on thyroid hormone (TH) homeostasis of rainbow trout (Oncorhynchus mykiss); mRNA levels of thyroid hormone receptors (TRs), TR alpha and TR beta, were determined by RT-PCR soon after sub-lethal administration in a static bio-assay system. The sub-lethal exposure of 0.84 mg/L amitraz resulted in upregulation of both TR alpha and TR beta genes for muscle and liver, respectively in a tissue-manner, though the differences were found statistically insignificant (P&amp;gt;0.05). The present results emerged an endocrine interaction between amitraz based formulation and TH homeostasis, but still needs further detail studies to a better understanding of TH mechanism in teleosts in response to environmental compounds.</subfield>
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    <subfield code="u">Ankara Univ, Dept Fisheries &amp; Aquaculture Engn, Fac Agr, Ankara, Turkey</subfield>
    <subfield code="a">Keskin, E.</subfield>
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