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Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-I in Human Breast Cancer

Timur, Selin Seda; Bhattarai, Prashant; Gursoy, Reyhan Neslihan; Vural, Imran; Khaw, Ban-An


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    "creators": [
      {
        "affiliation": "Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey", 
        "name": "Timur, Selin Seda"
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      {
        "affiliation": "Northeastern Univ, Dept Pharmaceut Sci, Sch Pharm, Bouve Coll Hlth Sci, 360 Huntington Ave, Boston, MA 02115 USA", 
        "name": "Bhattarai, Prashant"
      }, 
      {
        "affiliation": "Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey", 
        "name": "Gursoy, Reyhan Neslihan"
      }, 
      {
        "affiliation": "Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey", 
        "name": "Vural, Imran"
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      {
        "affiliation": "Northeastern Univ, Dept Pharmaceut Sci, Sch Pharm, Bouve Coll Hlth Sci, 360 Huntington Ave, Boston, MA 02115 USA", 
        "name": "Khaw, Ban-An"
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    "description": "Purpose LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use of LyP-1 as a targeting agent for the delivery of therapeutic or diagnostic agents. Peptide conjugates are developed for enhanced pretargeting of MDA-MB-231 breast cancer cells with peptideantibody bispecific complexes and targeting with multipledrug/- fluorophore-conjugated nano-polymers.", 
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      "issue": "2", 
      "pages": "352-364", 
      "title": "PHARMACEUTICAL RESEARCH", 
      "volume": "34"
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