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Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-I in Human Breast Cancer

Timur, Selin Seda; Bhattarai, Prashant; Gursoy, Reyhan Neslihan; Vural, Imran; Khaw, Ban-An


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/47829</identifier>
  <creators>
    <creator>
      <creatorName>Timur, Selin Seda</creatorName>
      <givenName>Selin Seda</givenName>
      <familyName>Timur</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bhattarai, Prashant</creatorName>
      <givenName>Prashant</givenName>
      <familyName>Bhattarai</familyName>
      <affiliation>Northeastern Univ, Dept Pharmaceut Sci, Sch Pharm, Bouve Coll Hlth Sci, 360 Huntington Ave, Boston, MA 02115 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Gursoy, Reyhan Neslihan</creatorName>
      <givenName>Reyhan Neslihan</givenName>
      <familyName>Gursoy</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Vural, Imran</creatorName>
      <givenName>Imran</givenName>
      <familyName>Vural</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Khaw, Ban-An</creatorName>
      <givenName>Ban-An</givenName>
      <familyName>Khaw</familyName>
      <affiliation>Northeastern Univ, Dept Pharmaceut Sci, Sch Pharm, Bouve Coll Hlth Sci, 360 Huntington Ave, Boston, MA 02115 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Design And In Vitro Evaluation Of Bispecific Complexes And Drug Conjugates Of Anticancer Peptide, Lyp-I In Human Breast Cancer</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/47829</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11095-016-2066-2</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Purpose LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use of LyP-1 as a targeting agent for the delivery of therapeutic or diagnostic agents. Peptide conjugates are developed for enhanced pretargeting of MDA-MB-231 breast cancer cells with peptideantibody bispecific complexes and targeting with multipledrug/- fluorophore-conjugated nano-polymers.</description>
  </descriptions>
</resource>
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