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CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism

Turan, Ihsan; Hutchins, B. Ian; Hacihamdioglu, Bulent; Kotan, L. Damla; Gurbuz, Fatih; Ulubay, Ayca; Mengen, Eda; Yuksel, Bilgin; Wray, Susan; Topaloglu, A. Kemal


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{
  "@context": "https://schema.org/", 
  "@id": 46747, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey", 
      "name": "Turan, Ihsan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "NINDS, Cellular & Dev Neurobiol Sect, NIH, Bethesda, MD 20892 USA", 
      "name": "Hutchins, B. Ian"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Haydarpasa Training Hosp, Gulhane Mil Med Acad, Dept Pediat, TR-34668 Istanbul, Turkey", 
      "name": "Hacihamdioglu, Bulent"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey", 
      "name": "Kotan, L. Damla"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey", 
      "name": "Gurbuz, Fatih"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Dept Forens Med, TR-01330 Adana, Turkey", 
      "name": "Ulubay, Ayca"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey", 
      "name": "Mengen, Eda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey", 
      "name": "Yuksel, Bilgin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "NINDS, Cellular & Dev Neurobiol Sect, NIH, Bethesda, MD 20892 USA", 
      "name": "Wray, Susan"
    }, 
    {
      "@type": "Person", 
      "name": "Topaloglu, A. Kemal"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Context: Gonadotropin-releasing hormone neurons originate outside the central nervous systemin the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons.", 
  "headline": "CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism", 
  "identifier": 46747, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism", 
  "url": "https://aperta.ulakbim.gov.tr/record/46747"
}
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