Published January 1, 2017
| Version v1
Journal article
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CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism
Creators
- 1. Cukurova Univ, Fac Med, Div Pediat Endocrinol, TR-01330 Adana, Turkey
- 2. NINDS, Cellular & Dev Neurobiol Sect, NIH, Bethesda, MD 20892 USA
- 3. Haydarpasa Training Hosp, Gulhane Mil Med Acad, Dept Pediat, TR-34668 Istanbul, Turkey
- 4. Cukurova Univ, Fac Med, Dept Forens Med, TR-01330 Adana, Turkey
Description
Context: Gonadotropin-releasing hormone neurons originate outside the central nervous systemin the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons.
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