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CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism

Turan, Ihsan; Hutchins, B. Ian; Hacihamdioglu, Bulent; Kotan, L. Damla; Gurbuz, Fatih; Ulubay, Ayca; Mengen, Eda; Yuksel, Bilgin; Wray, Susan; Topaloglu, A. Kemal


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{
  "DOI": "10.1210/jc.2016-3391", 
  "abstract": "Context: Gonadotropin-releasing hormone neurons originate outside the central nervous systemin the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons.", 
  "author": [
    {
      "family": "Turan", 
      "given": " Ihsan"
    }, 
    {
      "family": "Hutchins", 
      "given": " B. Ian"
    }, 
    {
      "family": "Hacihamdioglu", 
      "given": " Bulent"
    }, 
    {
      "family": "Kotan", 
      "given": " L. Damla"
    }, 
    {
      "family": "Gurbuz", 
      "given": " Fatih"
    }, 
    {
      "family": "Ulubay", 
      "given": " Ayca"
    }, 
    {
      "family": "Mengen", 
      "given": " Eda"
    }, 
    {
      "family": "Yuksel", 
      "given": " Bilgin"
    }, 
    {
      "family": "Wray", 
      "given": " Susan"
    }, 
    {
      "family": "Topaloglu", 
      "given": " A. Kemal"
    }
  ], 
  "container_title": "JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM", 
  "id": "46747", 
  "issue": "6", 
  "issued": {
    "date-parts": [
      [
        2017, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1816-1825", 
  "title": "CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism", 
  "type": "article-journal", 
  "volume": "102"
}
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