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Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors

Balcik-Ercin, Pelin; Cetin, Metin; Yalim-Camci, Irem; Odabas, Gorkem; Tokay, Nurettin; Sayan, A. Emre; Yagci, Tamer


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        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Balcik-Ercin, Pelin"
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      {
        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Cetin, Metin"
      }, 
      {
        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Yalim-Camci, Irem"
      }, 
      {
        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Odabas, Gorkem"
      }, 
      {
        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Tokay, Nurettin"
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      {
        "affiliation": "Univ Southampton, Canc Sci, Fac Med, Somers Bldg,Tremona Rd, Southampton SO16 6YD, Hants, England", 
        "name": "Sayan, A. Emre"
      }, 
      {
        "affiliation": "Gebze Tech Univ, Dept Mol Biol & Genet, Mol Oncol Lab, C2 Bldg, TR-41400 Gebze, Turkey", 
        "name": "Yagci, Tamer"
      }
    ], 
    "description": "ZEB2 is a transcriptional repressor that regulates epithelial-to-mesenchymal transition (EMT) through binding to bipartite E-box motifs in gene regulatory regions. Despite the abundant presence of E-boxes within the human genome and the multiplicity of pathophysiological processes regulated during ZEB2-induced EMT, only a small fraction of ZEB2 targets has been identified so far. Hence, we explored genome-wide ZEB2 binding by chromatin immunoprecipitation-sequencing (ChIP-seq) under endogenous ZEB2 expression conditions.", 
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      "pages": "379-393", 
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    "title": "Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors"
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