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Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents

Aktas, Derya Anil; Akinalp, Gokcen; Sanli, Fatma; Yucel, Mehmet Ali; Gambacorta, Nicola; Nicolotti, Orazio; Karatas, Omer Faruk; Algul, Oztekin; Burmaoglu, Serdar


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Aktas, Derya Anil</dc:creator>
  <dc:creator>Akinalp, Gokcen</dc:creator>
  <dc:creator>Sanli, Fatma</dc:creator>
  <dc:creator>Yucel, Mehmet Ali</dc:creator>
  <dc:creator>Gambacorta, Nicola</dc:creator>
  <dc:creator>Nicolotti, Orazio</dc:creator>
  <dc:creator>Karatas, Omer Faruk</dc:creator>
  <dc:creator>Algul, Oztekin</dc:creator>
  <dc:creator>Burmaoglu, Serdar</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/3571</dc:identifier>
  <dc:identifier>oai:zenodo.org:3571</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS 30(19)</dc:source>
  <dc:title>Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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