1 Ocak 2020 Dergi makalesi Açık Erişim

Aktas, Derya Anil; Akinalp, Gokcen; Sanli, Fatma; Yucel, Mehmet Ali; Gambacorta, Nicola; Nicolotti, Orazio; Karatas, Omer Faruk; Algul, Oztekin; Burmaoglu, Serdar

JSON

{
  "conceptrecid": "3570", 
  "created": "2021-03-15T05:47:35.208153+00:00", 
  "doi": "10.1016/j.bmcl.2020.127427", 
  "files": [
    {
      "bucket": "91379e95-ee30-42d3-9b5b-098b82137835", 
      "checksum": "md5:eb9951aeee0f93ba2ebe62c13272412c", 
      "key": "bib-fe1d8e32-5a7a-4fff-bf1d-294a1dde05ba.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/91379e95-ee30-42d3-9b5b-098b82137835/bib-fe1d8e32-5a7a-4fff-bf1d-294a1dde05ba.txt"
      }, 
      "size": 285, 
      "type": "txt"
    }
  ], 
  "id": 3571, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.bmcl.2020.127427.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/91379e95-ee30-42d3-9b5b-098b82137835", 
    "doi": "https://doi.org/10.1016/j.bmcl.2020.127427", 
    "html": "https://aperta.ulakbim.gov.tr/record/3571", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/3571", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/3571"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Ataturk Univ, Erzurum Vocat High Sch, Dept Chem & Chem Proc Technol, TR-25240 Erzurum, Turkey", 
        "name": "Aktas, Derya Anil"
      }, 
      {
        "affiliation": "Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey", 
        "name": "Akinalp, Gokcen"
      }, 
      {
        "name": "Sanli, Fatma"
      }, 
      {
        "name": "Yucel, Mehmet Ali"
      }, 
      {
        "affiliation": "Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy", 
        "name": "Gambacorta, Nicola"
      }, 
      {
        "affiliation": "Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy", 
        "name": "Nicolotti, Orazio"
      }, 
      {
        "name": "Karatas, Omer Faruk"
      }, 
      {
        "affiliation": "Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey", 
        "name": "Algul, Oztekin"
      }, 
      {
        "affiliation": "Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey", 
        "name": "Burmaoglu, Serdar"
      }
    ], 
    "description": "The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.", 
    "doi": "10.1016/j.bmcl.2020.127427", 
    "has_grant": false, 
    "journal": {
      "issue": "19", 
      "title": "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS", 
      "volume": "30"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2020-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "3571"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "3570"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 8.0, 
    "unique_downloads": 8.0, 
    "unique_views": 43.0, 
    "version_downloads": 8.0, 
    "version_unique_downloads": 8.0, 
    "version_unique_views": 43.0, 
    "version_views": 46.0, 
    "version_volume": 2280.0, 
    "views": 46.0, 
    "volume": 2280.0
  }, 
  "updated": "2021-03-15T05:47:35.257461+00:00"
}