1 Ocak 2020 Dergi makalesi Açık Erişim

Aktas, Derya Anil; Akinalp, Gokcen; Sanli, Fatma; Yucel, Mehmet Ali; Gambacorta, Nicola; Nicolotti, Orazio; Karatas, Omer Faruk; Algul, Oztekin; Burmaoglu, Serdar

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/3571</identifier>
  <creators>
    <creator>
      <creatorName>Aktas, Derya Anil</creatorName>
      <givenName>Derya Anil</givenName>
      <familyName>Aktas</familyName>
      <affiliation>Ataturk Univ, Erzurum Vocat High Sch, Dept Chem &amp; Chem Proc Technol, TR-25240 Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akinalp, Gokcen</creatorName>
      <givenName>Gokcen</givenName>
      <familyName>Akinalp</familyName>
      <affiliation>Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sanli, Fatma</creatorName>
      <givenName>Fatma</givenName>
      <familyName>Sanli</familyName>
    </creator>
    <creator>
      <creatorName>Yucel, Mehmet Ali</creatorName>
      <givenName>Mehmet Ali</givenName>
      <familyName>Yucel</familyName>
    </creator>
    <creator>
      <creatorName>Gambacorta, Nicola</creatorName>
      <givenName>Nicola</givenName>
      <familyName>Gambacorta</familyName>
      <affiliation>Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Nicolotti, Orazio</creatorName>
      <givenName>Orazio</givenName>
      <familyName>Nicolotti</familyName>
      <affiliation>Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Karatas, Omer Faruk</creatorName>
      <givenName>Omer Faruk</givenName>
      <familyName>Karatas</familyName>
    </creator>
    <creator>
      <creatorName>Algul, Oztekin</creatorName>
      <givenName>Oztekin</givenName>
      <familyName>Algul</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Burmaoglu, Serdar</creatorName>
      <givenName>Serdar</givenName>
      <familyName>Burmaoglu</familyName>
      <affiliation>Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Design, Synthesis And Biological Evaluation Of 3,5-Diaryl Isoxazole Derivatives As Potential Anticancer Agents</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/3571</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.bmcl.2020.127427</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.</description>
  </descriptions>
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