1 Ocak 2020 Dergi makalesi Açık Erişim

Aktas, Derya Anil; Akinalp, Gokcen; Sanli, Fatma; Yucel, Mehmet Ali; Gambacorta, Nicola; Nicolotti, Orazio; Karatas, Omer Faruk; Algul, Oztekin; Burmaoglu, Serdar

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{
  "@context": "https://schema.org/", 
  "@id": 3571, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Erzurum Vocat High Sch, Dept Chem & Chem Proc Technol, TR-25240 Erzurum, Turkey", 
      "name": "Aktas, Derya Anil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey", 
      "name": "Akinalp, Gokcen"
    }, 
    {
      "@type": "Person", 
      "name": "Sanli, Fatma"
    }, 
    {
      "@type": "Person", 
      "name": "Yucel, Mehmet Ali"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy", 
      "name": "Gambacorta, Nicola"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Via E Orabona 4, I-70125 Bari, Italy", 
      "name": "Nicolotti, Orazio"
    }, 
    {
      "@type": "Person", 
      "name": "Karatas, Omer Faruk"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey", 
      "name": "Algul, Oztekin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey", 
      "name": "Burmaoglu, Serdar"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.", 
  "headline": "Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents", 
  "identifier": 3571, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents", 
  "url": "https://aperta.ulakbim.gov.tr/record/3571"
}