1 Ocak 2018 Dergi makalesi Açık Erişim

Gokduman, Kurtulus; Bestepe, Furkan; Li, Lei; Yarmush, Martin L.; Usta, O. Berk

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{
  "@context": "https://schema.org/", 
  "@id": 29055, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA", 
      "name": "Gokduman, Kurtulus"
    }, 
    {
      "@type": "Person", 
      "name": "Bestepe, Furkan"
    }, 
    {
      "@type": "Person", 
      "name": "Li, Lei"
    }, 
    {
      "@type": "Person", 
      "name": "Yarmush, Martin L."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA", 
      "name": "Usta, O. Berk"
    }
  ], 
  "datePublished": "2018-01-01", 
  "description": "Aim: As a first study in literature, to investigate concentration-dependent (0-400 mu g/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. Materials & methods: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. Results: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner. In terms of hepatocyte-specific functions, cumulative dosing caused significantly (p < 0.05) more deleterious effects at 48th hour. Conclusion: A combination of various biomarkers should be employed for the evaluation of the effect of superparamagnetic iron oxide nanoparticles on liver, and each biomarker should be analyzed in a time- and exposure-dependent manner.", 
  "headline": "Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes", 
  "identifier": 29055, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes", 
  "url": "https://aperta.ulakbim.gov.tr/record/29055"
}