1 Ocak 2018 Dergi makalesi Açık Erişim

Gokduman, Kurtulus; Bestepe, Furkan; Li, Lei; Yarmush, Martin L.; Usta, O. Berk

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/29055</identifier>
  <creators>
    <creator>
      <creatorName>Gokduman, Kurtulus</creatorName>
      <givenName>Kurtulus</givenName>
      <familyName>Gokduman</familyName>
      <affiliation>Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Bestepe, Furkan</creatorName>
      <givenName>Furkan</givenName>
      <familyName>Bestepe</familyName>
    </creator>
    <creator>
      <creatorName>Li, Lei</creatorName>
      <givenName>Lei</givenName>
      <familyName>Li</familyName>
    </creator>
    <creator>
      <creatorName>Yarmush, Martin L.</creatorName>
      <givenName>Martin L.</givenName>
      <familyName>Yarmush</familyName>
    </creator>
    <creator>
      <creatorName>Usta, O. Berk</creatorName>
      <givenName>O. Berk</givenName>
      <familyName>Usta</familyName>
      <affiliation>Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Dose-, Treatment- And Time-Dependent Toxicity Of Superparamagnetic Iron Oxide Nanoparticles On Primary Rat Hepatocytes</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/29055</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2217/nnm-2017-0387</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Aim: As a first study in literature, to investigate concentration-dependent (0-400 mu g/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. Materials &amp;amp; methods: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. Results: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner. In terms of hepatocyte-specific functions, cumulative dosing caused significantly (p &amp;lt; 0.05) more deleterious effects at 48th hour. Conclusion: A combination of various biomarkers should be employed for the evaluation of the effect of superparamagnetic iron oxide nanoparticles on liver, and each biomarker should be analyzed in a time- and exposure-dependent manner.</description>
  </descriptions>
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