1 Ocak 2018 Dergi makalesi Açık Erişim

Gokduman, Kurtulus; Bestepe, Furkan; Li, Lei; Yarmush, Martin L.; Usta, O. Berk

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    "creators": [
      {
        "affiliation": "Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA", 
        "name": "Gokduman, Kurtulus"
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      {
        "name": "Bestepe, Furkan"
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      {
        "name": "Li, Lei"
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      {
        "name": "Yarmush, Martin L."
      }, 
      {
        "affiliation": "Harvard Med Sch, Massachusetts Gen Hosp, Shriners Hosp, Ctr Engn Med, Boston, MA 02114 USA", 
        "name": "Usta, O. Berk"
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    "description": "Aim: As a first study in literature, to investigate concentration-dependent (0-400 mu g/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. Materials & methods: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. Results: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner. In terms of hepatocyte-specific functions, cumulative dosing caused significantly (p < 0.05) more deleterious effects at 48th hour. Conclusion: A combination of various biomarkers should be employed for the evaluation of the effect of superparamagnetic iron oxide nanoparticles on liver, and each biomarker should be analyzed in a time- and exposure-dependent manner.", 
    "doi": "10.2217/nnm-2017-0387", 
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    "journal": {
      "issue": "11", 
      "pages": "1267-1284", 
      "title": "NANOMEDICINE", 
      "volume": "13"
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    "title": "Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes"
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