1 Ocak 2018 Dergi makalesi Açık Erişim

Gokduman, Kurtulus; Bestepe, Furkan; Li, Lei; Yarmush, Martin L.; Usta, O. Berk

Citation Style Language JSON

{
  "DOI": "10.2217/nnm-2017-0387", 
  "abstract": "Aim: As a first study in literature, to investigate concentration-dependent (0-400 mu g/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. Materials & methods: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. Results: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner. In terms of hepatocyte-specific functions, cumulative dosing caused significantly (p < 0.05) more deleterious effects at 48th hour. Conclusion: A combination of various biomarkers should be employed for the evaluation of the effect of superparamagnetic iron oxide nanoparticles on liver, and each biomarker should be analyzed in a time- and exposure-dependent manner.", 
  "author": [
    {
      "family": "Gokduman", 
      "given": " Kurtulus"
    }, 
    {
      "family": "Bestepe", 
      "given": " Furkan"
    }, 
    {
      "family": "Li", 
      "given": " Lei"
    }, 
    {
      "family": "Yarmush", 
      "given": " Martin L."
    }, 
    {
      "family": "Usta", 
      "given": " O. Berk"
    }
  ], 
  "container_title": "NANOMEDICINE", 
  "id": "29055", 
  "issue": "11", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1267-1284", 
  "title": "Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes", 
  "type": "article-journal", 
  "volume": "13"
}