5 Temmuz 2024 Diğer Açık Erişim

Köse, Sıla Naz; Yaraş, Tutku; Bursalı, Ahmet; Oktay, Yavuz; Yandım, Cihangir; Karakülah, Gökhan

JSON-LD (schema.org)

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  "@context": "https://schema.org/", 
  "@id": 273725, 
  "@type": "CreativeWork", 
  "creator": [
    {
      "@id": "https://orcid.org/0000-0003-2358-1605", 
      "@type": "Person", 
      "affiliation": "Izmir University of Economics", 
      "name": "K\u00f6se, S\u0131la Naz"
    }, 
    {
      "@id": "https://orcid.org/0000-0003-3019-7900", 
      "@type": "Person", 
      "affiliation": "Izmir Biomedicine and Genome Center", 
      "name": "Yara\u015f, Tutku"
    }, 
    {
      "@id": "https://orcid.org/0000-0001-7050-769X", 
      "@type": "Person", 
      "affiliation": "Izmir Biomedicine and Genome Center", 
      "name": "Bursal\u0131, Ahmet"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-0158-2693", 
      "@type": "Person", 
      "affiliation": "Izmir Biomedicine and Genome Center", 
      "name": "Oktay, Yavuz"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-2050-6186", 
      "@type": "Person", 
      "affiliation": "Izmir University of Economics", 
      "name": "Yand\u0131m, Cihangir"
    }, 
    {
      "@id": "https://orcid.org/0000-0001-6706-1375", 
      "@type": "Person", 
      "affiliation": "Izmir Biomedicine and Genome Center", 
      "name": "Karak\u00fclah, G\u00f6khan"
    }
  ], 
  "datePublished": "2024-07-05", 
  "description": "<p>The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma&#39;s molecular pathology and patient survival remains largely unexplored. In this study, we aimed to to characterize the links between the expressions of repeat / transposable elements with disease progression and survival in glioma patients. Hence, we analyzed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, 22 transposons and the HSAT5 satellite repeat were linked to a shorter event-free survival in HGG patients. Intriguingly, our weighted gene co-expression network analysis (WGCNA) disclosed that the HSAT5 satellite repeat resided in the same module network with genes implicated in chromosome segregation and nuclear division; potentially hinting at its contribution to disease pathogenesis. Collectively, we report for the first time that repeat and/or transposon expression could be related to disease progression and survival in glioma. The expressions of these elements seem to exert a protective effect during LGG-to-HGG progression, whereas they could have a detrimental impact once HGG is established. The results presented herein could serve as a foundation for further experimental work aimed at elucidating the molecular regulation of glioma genome.</p>", 
  "identifier": 273725, 
  "inLanguage": {
    "@type": "Language", 
    "alternateName": "eng", 
    "name": "English"
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  "keywords": [
    "Glioma", 
    "Glioblastoma", 
    "Transposon", 
    "Satellite Repeat", 
    "HSAT5", 
    "Survival"
  ], 
  "license": "https://creativecommons.org/licenses/by-nc-sa/4.0/", 
  "name": "Expressions of the satellite repeat HSAT5 and transposable elements are implicated in disease progression and survival in glioma (Supplementary Files)", 
  "url": "https://aperta.ulakbim.gov.tr/record/273725"
}