5 Temmuz 2024 Diğer Açık Erişim

Köse, Sıla Naz; Yaraş, Tutku; Bursalı, Ahmet; Oktay, Yavuz; Yandım, Cihangir; Karakülah, Gökhan

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        "affiliation": "Izmir University of Economics", 
        "name": "K\u00f6se, S\u0131la Naz", 
        "orcid": "0000-0003-2358-1605"
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        "affiliation": "Izmir Biomedicine and Genome Center", 
        "name": "Yara\u015f, Tutku", 
        "orcid": "0000-0003-3019-7900"
      }, 
      {
        "affiliation": "Izmir Biomedicine and Genome Center", 
        "name": "Bursal\u0131, Ahmet", 
        "orcid": "0000-0001-7050-769X"
      }, 
      {
        "affiliation": "Izmir Biomedicine and Genome Center", 
        "name": "Oktay, Yavuz", 
        "orcid": "0000-0002-0158-2693"
      }, 
      {
        "affiliation": "Izmir University of Economics", 
        "name": "Yand\u0131m, Cihangir", 
        "orcid": "0000-0002-2050-6186"
      }, 
      {
        "affiliation": "Izmir Biomedicine and Genome Center", 
        "name": "Karak\u00fclah, G\u00f6khan", 
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    "description": "<p>The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma&#39;s molecular pathology and patient survival remains largely unexplored. In this study, we aimed to to characterize the links between the expressions of repeat / transposable elements with disease progression and survival in glioma patients. Hence, we analyzed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, 22 transposons and the HSAT5 satellite repeat were linked to a shorter event-free survival in HGG patients. Intriguingly, our weighted gene co-expression network analysis (WGCNA) disclosed that the HSAT5 satellite repeat resided in the same module network with genes implicated in chromosome segregation and nuclear division; potentially hinting at its contribution to disease pathogenesis. Collectively, we report for the first time that repeat and/or transposon expression could be related to disease progression and survival in glioma. The expressions of these elements seem to exert a protective effect during LGG-to-HGG progression, whereas they could have a detrimental impact once HGG is established. The results presented herein could serve as a foundation for further experimental work aimed at elucidating the molecular regulation of glioma genome.</p>", 
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    "journal": {
      "title": "Turkish Journal of Biology"
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      "Glioma", 
      "Glioblastoma", 
      "Transposon", 
      "Satellite Repeat", 
      "HSAT5", 
      "Survival"
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    "notes": "Supplementary Files for the article to be published in the Turkish Journal of Biology.", 
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    "science_branches": [
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik > Kanser Molek\u00fcler Biyolojisi", 
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik", 
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik > Genomiks"
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    "title": "Expressions of the satellite repeat HSAT5 and transposable elements are implicated in disease progression and survival in glioma (Supplementary Files)"
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