5 Temmuz 2024 Diğer Açık Erişim

Köse, Sıla Naz; Yaraş, Tutku; Bursalı, Ahmet; Oktay, Yavuz; Yandım, Cihangir; Karakülah, Gökhan

Citation Style Language JSON

{
  "URL": "https://aperta.ulakbim.gov.tr/record/273725", 
  "abstract": "<p>The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma&#39;s molecular pathology and patient survival remains largely unexplored. In this study, we aimed to to characterize the links between the expressions of repeat / transposable elements with disease progression and survival in glioma patients. Hence, we analyzed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, 22 transposons and the HSAT5 satellite repeat were linked to a shorter event-free survival in HGG patients. Intriguingly, our weighted gene co-expression network analysis (WGCNA) disclosed that the HSAT5 satellite repeat resided in the same module network with genes implicated in chromosome segregation and nuclear division; potentially hinting at its contribution to disease pathogenesis. Collectively, we report for the first time that repeat and/or transposon expression could be related to disease progression and survival in glioma. The expressions of these elements seem to exert a protective effect during LGG-to-HGG progression, whereas they could have a detrimental impact once HGG is established. The results presented herein could serve as a foundation for further experimental work aimed at elucidating the molecular regulation of glioma genome.</p>", 
  "author": [
    {
      "family": "K\u00f6se", 
      "given": " S\u0131la Naz"
    }, 
    {
      "family": "Yara\u015f", 
      "given": " Tutku"
    }, 
    {
      "family": "Bursal\u0131", 
      "given": " Ahmet"
    }, 
    {
      "family": "Oktay", 
      "given": " Yavuz"
    }, 
    {
      "family": "Yand\u0131m", 
      "given": " Cihangir"
    }, 
    {
      "family": "Karak\u00fclah", 
      "given": " G\u00f6khan"
    }
  ], 
  "container_title": "Turkish Journal of Biology", 
  "id": "273725", 
  "issued": {
    "date-parts": [
      [
        2024, 
        7, 
        5
      ]
    ]
  }, 
  "language": "eng", 
  "note": "Supplementary Files for the article to be published in the Turkish Journal of Biology.", 
  "title": "Expressions of the satellite repeat HSAT5 and transposable elements are implicated in disease progression and survival in glioma (Supplementary Files)", 
  "type": "article"
}