5 Temmuz 2024 Diğer Açık Erişim

Köse, Sıla Naz; Yaraş, Tutku; Bursalı, Ahmet; Oktay, Yavuz; Yandım, Cihangir; Karakülah, Gökhan

DataCite XML

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  <identifier identifierType="DOI">10.48623/aperta.273725</identifier>
  <creators>
    <creator>
      <creatorName>Köse, Sıla Naz</creatorName>
      <givenName>Sıla Naz</givenName>
      <familyName>Köse</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2358-1605</nameIdentifier>
      <affiliation>Izmir University of Economics</affiliation>
    </creator>
    <creator>
      <creatorName>Yaraş, Tutku</creatorName>
      <givenName>Tutku</givenName>
      <familyName>Yaraş</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-3019-7900</nameIdentifier>
      <affiliation>Izmir Biomedicine and Genome Center</affiliation>
    </creator>
    <creator>
      <creatorName>Bursalı, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Bursalı</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7050-769X</nameIdentifier>
      <affiliation>Izmir Biomedicine and Genome Center</affiliation>
    </creator>
    <creator>
      <creatorName>Oktay, Yavuz</creatorName>
      <givenName>Yavuz</givenName>
      <familyName>Oktay</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0158-2693</nameIdentifier>
      <affiliation>Izmir Biomedicine and Genome Center</affiliation>
    </creator>
    <creator>
      <creatorName>Yandım, Cihangir</creatorName>
      <givenName>Cihangir</givenName>
      <familyName>Yandım</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-2050-6186</nameIdentifier>
      <affiliation>Izmir University of Economics</affiliation>
    </creator>
    <creator>
      <creatorName>Karakülah, Gökhan</creatorName>
      <givenName>Gökhan</givenName>
      <familyName>Karakülah</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6706-1375</nameIdentifier>
      <affiliation>Izmir Biomedicine and Genome Center</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Expressions Of The Satellite Repeat Hsat5 And Transposable Elements Are Implicated In Disease Progression And Survival In Glioma (Supplementary Files)</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2024</publicationYear>
  <subjects>
    <subject>Glioma</subject>
    <subject>Glioblastoma</subject>
    <subject>Transposon</subject>
    <subject>Satellite Repeat</subject>
    <subject>HSAT5</subject>
    <subject>Survival</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2024-07-05</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Other"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/273725</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.48623/aperta.273724</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma&amp;#39;s molecular pathology and patient survival remains largely unexplored. In this study, we aimed to to characterize the links between the expressions of repeat / transposable elements with disease progression and survival in glioma patients. Hence, we analyzed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, 22 transposons and the HSAT5 satellite repeat were linked to a shorter event-free survival in HGG patients. Intriguingly, our weighted gene co-expression network analysis (WGCNA) disclosed that the HSAT5 satellite repeat resided in the same module network with genes implicated in chromosome segregation and nuclear division; potentially hinting at its contribution to disease pathogenesis. Collectively, we report for the first time that repeat and/or transposon expression could be related to disease progression and survival in glioma. The expressions of these elements seem to exert a protective effect during LGG-to-HGG progression, whereas they could have a detrimental impact once HGG is established. The results presented herein could serve as a foundation for further experimental work aimed at elucidating the molecular regulation of glioma genome.&lt;/p&gt;</description>
    <description descriptionType="Other">Supplementary Files for the article to be published in the Turkish Journal of Biology.</description>
  </descriptions>
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