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Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Karaduman, Aysenur; Keskus, Ayse Gokce; Arslan-Ergul, Ayca; Konu, Ozlen; Kafaligonul, Hulusi; Adams, Michelle M.
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Tuz-Sasik, Melek Umay</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Karaduman, Aysenur</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Keskus, Ayse Gokce</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Arslan-Ergul, Ayca</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Konu, Ozlen</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kafaligonul, Hulusi</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Adams, Michelle M.</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">GERONTOLOGY</subfield> <subfield code="v">69</subfield> <subfield code="n">12</subfield> <subfield code="c">13</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1159/000534343</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Karoglu-Eravsar, Elif Tugce</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:270528</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2023-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/270528/files/bib-78357f6d-e8b6-4e65-b253-7e3b7fe25eb7.txt</subfield> <subfield code="z">md5:7618b5b4084ca314e6b09b436641f93b</subfield> <subfield code="s">322</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20240607155336.0</controlfield> <controlfield tag="001">270528</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Discussion/Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects.</p></subfield> </datafield> </record>
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