1 Ocak 2023 Dergi makalesi Açık Erişim

Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Karaduman, Aysenur; Keskus, Ayse Gokce; Arslan-Ergul, Ayca; Konu, Ozlen; Kafaligonul, Hulusi; Adams, Michelle M.

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        "name": "Karoglu-Eravsar, Elif Tugce"
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      {
        "name": "Tuz-Sasik, Melek Umay"
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      {
        "name": "Karaduman, Aysenur"
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      {
        "name": "Keskus, Ayse Gokce"
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      {
        "name": "Arslan-Ergul, Ayca"
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      {
        "name": "Konu, Ozlen"
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      {
        "name": "Kafaligonul, Hulusi"
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      {
        "name": "Adams, Michelle M."
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    "description": "<p>Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Discussion/Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects.</p>", 
    "doi": "10.1159/000534343", 
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      "issue": "12", 
      "pages": "13", 
      "title": "GERONTOLOGY", 
      "volume": "69"
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    "title": "Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain"
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