1 Ocak 2023 Dergi makalesi Açık Erişim

Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Karaduman, Aysenur; Keskus, Ayse Gokce; Arslan-Ergul, Ayca; Konu, Ozlen; Kafaligonul, Hulusi; Adams, Michelle M.

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{
  "@context": "https://schema.org/", 
  "@id": 270528, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Karoglu-Eravsar, Elif Tugce"
    }, 
    {
      "@type": "Person", 
      "name": "Tuz-Sasik, Melek Umay"
    }, 
    {
      "@type": "Person", 
      "name": "Karaduman, Aysenur"
    }, 
    {
      "@type": "Person", 
      "name": "Keskus, Ayse Gokce"
    }, 
    {
      "@type": "Person", 
      "name": "Arslan-Ergul, Ayca"
    }, 
    {
      "@type": "Person", 
      "name": "Konu, Ozlen"
    }, 
    {
      "@type": "Person", 
      "name": "Kafaligonul, Hulusi"
    }, 
    {
      "@type": "Person", 
      "name": "Adams, Michelle M."
    }
  ], 
  "datePublished": "2023-01-01", 
  "description": "<p>Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Discussion/Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects.</p>", 
  "headline": "Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain", 
  "identifier": 270528, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain", 
  "url": "https://aperta.ulakbim.gov.tr/record/270528"
}